Adult Neurofibromatosis Type 1 (NF1) and Schwannomatosis Clinic

A Study of a New Way to Treat Children and Young Adults With a Brain Tumor Called NGGCT

Will be measured by the number of progressions or deaths within 2 years of enrollment for the cohort treated with whole ventricular + spinal canal irradiation (WVSCI). The final analysis will include an exact binomial confidence i...

Recruiting

Evaluating a Low-Cost Therapeutic Device in Managing Head and Neck Cancer Patients With Radiati...

The mean change in MIO from baseline to end of treatment at 6 weeks will be reported

Recruiting

A Study to See if Memantine Protects the Brain During Radiation Therapy Treatment for Primary C...

We will estimate the difference in mean Cogstate composite Z score slopes (reflecting change in Cogstate composite Z scores from baseline to 12 months post baseline taking into account measurements at those time points as well as ...

Recruiting

A Study of the Drug Selinexor With Radiation Therapy in Patients With Newly-Diagnosed Diffuse I...

Defined as the highest dose of selinexor in combination with standard of care radiation therapy (RT) that does not cause unacceptable side effects.

Recruiting

A Study of the Drugs Selumetinib Versus Carboplatin/Vincristine in Patients With Neurofibromato...

EFS is defined as time from randomization to the first occurrence of any of the following events: clinical or radiographic disease progression, disease recurrence, second malignant neoplasm, or death from any cause. Patients who a...

Recruiting

Optic Nerve Stimulation To Prevent Visual Deficits After Endoscopic Cranial Approaches

Patients that received our intervention will be evaluated post operatively for regular standard of care six weeks post-operatively. During visual evaluation, the PI of this study will determine post-operative visual field and visu...

Recruiting

A Study of the Drugs Selumetinib vs. Carboplatin and Vincristine in Patients With Low-Grade Gli...

The Kaplan-Meier method will be used to estimate EFS which is defined as the interval from randomization to first occurrence of clinical or radiographic disease progression, disease recurrence, second malignant neoplasm, or death ...

Recruiting

ICG Angiogram as a Predictor of Postoperative Visual Function After EEA Surgery

The investigators will evaluate the percentage of participants that present with decreased of visual acuity and any modality of visual field defect after the surgery. Postoperative visual acuity and visual field testing will be pe...

Recruiting

Study of Nivolumab and Ipilimumab in Children and Young Adults With INI1-Negative Cancers

Based on Response Evaluation in Solid Tumors (RECIST) version 1.1

Recruiting